Immune correlates of protection against anthrax
نویسندگان
چکیده
منابع مشابه
CA-074Me protection against anthrax lethal toxin.
Anthrax lethal toxin (LT) activates the NLRP1b (NALP1b) inflammasome and caspase-1 in macrophages from certain inbred mouse strains, but the mechanism by which this occurs is poorly understood. We report here that similar to several NLRP3 (NALP3, cryopyrin)-activating stimuli, LT activation of the NLRP1b inflammasome involves lysosomal membrane permeabilization (LMP) and subsequent cytoplasmic ...
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BACKGROUND The BCG vaccine is ineffective against adult tuberculosis. Hence, new antituberculosis vaccines are needed. Correlates of protection against tuberculosis are not known. We studied the effects of BCG vaccination on gene expression in tuberculosis granulomas using macaques. METHODS Macaques were BCG-vaccinated or sham-vaccinated and then challenged with virulent Mycobacterium tubercu...
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ژورنال
عنوان ژورنال: Journal of Applied Microbiology
سال: 1999
ISSN: 1364-5072,1365-2672
DOI: 10.1046/j.1365-2672.1999.00898.x